eSeminar: Impaired mitochondrial β-oxidation in cardiomyocytes: role of the cardiac renin-angiotensin system and miR-208

24. 1. 2018


Diabetic cardiomyopathy is a common complication in type 2 diabetes. In our research we showed that hormones derived from epicardial adipose tissue promote the induction of miR-208a via activation of the renin-angiotensin system. In cardiomyocytes, induction of miR208a results in inhibition of cardiac contractile function and inhibition of fatty acid oxidation.
In this webinar we will discuss:
Analysis of mitochondrial function in cardiomyocytes using Agilent Seahorse XF technology
Application of mito stress test, glycolysis stress test and palmitate oxidation assays in HL-1 cardiomyocytes

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