30. 4. 2018
Ion mobility/mass spectrometry has tremendous potential for metabolomics, lipidomics, and clinical analysis. Ion mobility can resolve compounds unresolved by LC/MS/MS, provide additional structural information not available from mass spectrometry, and reduce or eliminate the need for chromatographic separation. These features offer significant improvements for quantitative targeted metabolomics and clinical research analysis, as well as for untargeted (global) metabolomics studies.
This presentation will explore innovations in ion mobility/mass spectrometry for metabolomics, lipidomics, and clinical research analysis. Techniques to be covered include both classic drift tube ion mobility (IMS) and high‐field asymmetric‐waveform ion mobility (FAIMS), in conjunction with HRMS, MS/MS, and LC/MS. Characterization and optimization of instrumental parameters critical for analytical performance will be explored, including ionization techniques, cationization and complexation of analytes for improved mobility separation, and integration with chromatographic separation and MS/MS. Applications will include a range of metabolomics, lipidomics, and targeted clinical research analyses. Specific examples will include rapid clinical research assays (vitamin D and its epimers), separation of isomeric performance‐enhancing steroids, breath analysis research for potential early disease screening, and improvements in mass spec imaging. Recent advances in these areas will be highlighted, along with a perspective on the metabolomics and clinical future of these approaches.
To understand how ion mobility is combined with mass spectrometry
To understand how in mobility/mass spectrometry can be used for clinical research analysis and metabolomics
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