eSeminar (posnetek) – Metabolic switches that drive stem cell specification and differentiation to a mature neuron


As pluripotent stem cells become specified towards a neural stem/progenitor cell and then further differentiate into a mature neural cell type, they go through a number of molecular and metabolic changes that shift the balance between glycolysis and oxidative phosphorylation. Through the differentiation process stem cells turn off their dependence on glycolysis and move towards oxidative phosphorylation. However, whether the lineage specific gene expression drives the metabolic switch or vice versa remains unknown and is an aspect the we will further explore in this webinar.
In this webinar we will discuss:
How metabolism changes during differentiation from a stem cell
How to analyze the metabolic switch in human pluripotent stem cells, stem/progenitor cells and mature peripheral neurons
How to use the Seahorse XF Analyzer to study human neural differentiation and neurodegenerative diseases.
Eva Szabo, MSc, PhD
Canada Research Chair in Metabolism in Human Stem Cells and Cancer Development
Principal Investigator – Stem Cell and Cancer Research Institute (SCC-RI)
Assistant Professor – Biochemistry and Biomedical Sciences and Department of Medicine
Michael G. DeGroote School of Medicine
McMaster University

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