Expand Your Drug Discovery Pipeline – Target cell metabolism pathways


The critical pathway you may not have considered
The dysregulation of cellular metabolism is frequently observed in disease states, from cancer and diabetes, through to neurodegeneration. Investigating cellular metabolism in your target identification and validation studies therefore delivers an opportunity to expand your drug discovery pipeline, opening new avenues of therapeutic intervention.
Although metabolism seems complex, you don’t need to be an expert to generate meaningful insights. Discover the essential metabolic pathways for your drug discovery studies with this interactive metabolic map.
Immunology
Cancer
Neuroscience
Acquired Metabolic Diseases
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Pathways
Fatty acid oxidation
Glycolysis
Electron transport chain
Disease
Autoimmune disorders, inflammation, allergies, blood born cancers, infection, immunosuppression, tumor microenvironments
Function
Immune cells undergo changes in cellular metabolism to support their function and plasticity. Targeting immune cell metabolism is a promising strategy for selective regulation of immune responses.
Relevant Publication
Mills et al. Mitochondria are the Powerhouses of Immunity. Nature Immunology, 18, 488–498, 2017. doi: 10.1038/ni.3704.
Pearce, E. J. and Pearce, E. L. Driving immunity: all roads lead to metabolism. Nature Reviews immunology, 18, 81–82, 2018, doi: 10.1038/nri.2017.139
Fatty acid oxidation
Glycolysis
Electron transport chain
Discover the power of functional metabolic measurements
Find out how you can start incorporating metabolism into your research by reading our Application Brief “Gaining Insights into disease biology for Target Identification and Validation”.
In it, you’ll discover how Seahorse XF Technology has been used to advance the understanding of potential drug targets in several therapeutic areas.
Gaining Insights into disease biology for Target Identification and Validation
Download now
Agilent metabolic measurement solutions
Enhance your drug discovery workflow with live cell, real‐time metabolic analysis solutions from Agilent. Learn more about our solutions.
Agilent Seahorse XFe96 platforms
Agilent Seahorse XFe96 platforms
MitoXpress Xtra and pH Xtra assays
MitoXpress Xtra and pH Xtra assays
Bravo Automation workflow
Bravo Automation workflow
Streamlined sample preparation workflow to deliver actionable results from your live‐cell analysis
The Bravo automated liquid handling platform coupled with Bravo Seahorse Assay Workbench software streamlines your Seahorse XFe96 assay preparation. Generate the results you need while saving labor in the lab, increasing walk‐away time, and achieving consistent data quality. Learn more

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