Nitrosamines Analysis in Drinking Water Using GC/MS/MS – Meeting Equivalence to EPA Method 521

The Eurofins Eaton Analytical-Agilent Method 521.1 (EEA-Agilent Method 521.1) is based on a multilaboratory study of nitrosamines in drinking water using triple quadrupole GC/MS (GC/MS/MS) in electron ionization (EI) mode1 . Currently, ion trap GC/MS (GC/IT) is the approved technology for the United States Environmental Protection Agency (EPA) Method 521, but GC-IT is being obsoleted. The EPA was open to approval of alternate detection methods as long as the sample preparation step was unchanged. Analytes in EPA Method 521 were investigated with the addition of N-nitrosomorpholine (NMOR). The study was divided into two phases. In phase I, Lab A demonstrated that GC/MS/MS achieved lower lowest concentration minimum reporting levels (LCMRL) and detection limits (DL) than the approved GC/IT. Lower injection volume and shorter analysis times were accomplished with the GC/MS/MS. Good correlation between GC/MS/MS and GC/IT was observed when analyzing nitrosamines in numerous field samples. In phase II, Lab A extracts and splits LCMRL samples (32) to Lab B and Lab C for validation using Agilent 7010 and 7000 GC/MS/MS systems, respectively. Both 7010 and 7000 GC/MS/MS results were better than the LCMRL and DL requirements in Method 521. A linear calibration curve was achieved with R2 >0.99. Method performance was verified by three separate laboratories and the EPA has provided a letter of method equivalency. Za odpiranje dokumenta
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