Agilent SW Tools for MS Based Multi-omics Studies

The central dogma for biological information fl ow is expressed as a series of chemical
conversions (Figure 1) that ultimately defi ne an organism’s biological phenotype. Since
the products of enzymatic turnover are metabolites, and, because the sum of all primary
and secondary metabolites is most closely associated with an organism’s phenotype,
mass spectrometry based, joint proteomics, and metabolomics (multi-omics) studies
offer advantages over a single-omics analysis. For example, a multi-omics experiment
can help us better understand some of the complex regulatory steps that determine the
resulting phenotype, and why biology is not simply the sum of its parts.

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