The Eurofins Eaton Analytical-Agilent Method 521.1 (EEA-Agilent Method 521.1)
is based on a multilaboratory study of nitrosamines in drinking water using triple
quadrupole GC/MS (GC/MS/MS) in electron ionization (EI) mode1
. Currently, ion
trap GC/MS (GC/IT) is the approved technology for the United States Environmental
Protection Agency (EPA) Method 521, but GC-IT is being obsoleted. The EPA was
open to approval of alternate detection methods as long as the sample preparation
step was unchanged. Analytes in EPA Method 521 were investigated with the
addition of N-nitrosomorpholine (NMOR). The study was divided into two phases. In
phase I, Lab A demonstrated that GC/MS/MS achieved lower lowest concentration
minimum reporting levels (LCMRL) and detection limits (DL) than the approved
GC/IT. Lower injection volume and shorter analysis times were accomplished with
the GC/MS/MS. Good correlation between GC/MS/MS and GC/IT was observed
when analyzing nitrosamines in numerous field samples. In phase II, Lab A extracts
and splits LCMRL samples (32) to Lab B and Lab C for validation using Agilent 7010
and 7000 GC/MS/MS systems, respectively. Both 7010 and 7000 GC/MS/MS results
were better than the LCMRL and DL requirements in Method 521. A linear calibration
curve was achieved with R2
>0.99. Method performance was verified by three
separate laboratories and the EPA has provided a letter of method equivalency.
Za odpiranje dokumenta
kliknite tukaj …
01 4277 560
Ne zamudite naših prihodnjih dogodkov in obvestil
Digitalna preobrazba podjetja Chemass
Discuss with Agilent